"Jacques Futrelle: The Last Story" is a historical fiction piece centered on the real-life mystery writer, Jacques Futrelle, and his wife, Lily, as they sail home to America aboard the luxurious RMS Titanic. Futrelle carries with him a briefcase containing his most valuable asset: the final manuscripts for his popular detective series. Amidst the conviviality of first-class society, where they socialize with figures like Colonel John Jacob Astor and Molly Brown, an emotional tension builds as Lily worries about the security of the precious stories.